Unreliable assessment of necrotic core by virtual histology intravascular ultrasound in porcine coronary artery disease.

Letter by Stone and Mintz regarding article, "unreliable assessment of necrotic core by virtual histology intravascular ultrasound in porcine coronary artery disease".

Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease.

BACKGROUND Experimental studies suggest that low wall shear stress (WSS) promotes plaque development and high WSS is associated with plaque destabilization. We hypothesized that low-WSS segments in patients with coronary artery disease develop plaque progression and high-WSS segments develop necrotic core progression with fibrous tissue regression. METHODS AND RESULTS Twenty patients with cor...

Hypercholesterolemia and In-Vivo Coronary Plaque Composition in Patients with Coronary Artery Disease: A Virtual Histology - Intravascular Ultrasound Study

BACKGROUND AND OBJECTIVES Hypercholesterolemia is a key factor in the development of atherosclerosis. We sought to evaluate the relation between hypercholesterolemia and plaque composition in patients with coronary artery disease. SUBJECTS AND METHODS Study subjects consisted of 323 patients (mean 61.5 years, 226 males) who underwent coronary angiography and virtual histology-intravascular ul...

An auscultatory conundrum: severe mitral stenosis with a third heart sound?

Unreliable assessment of necrotic core by virtual histology intravascular ultrasound in porcine coronary artery disease/clinical perspective. Circ Cardiovasc Imaging 2010; 3:384–91. 26. Waxman S, Dixon SR, L’Allier P, Moses JW, Petersen JL, Cutlip D et al. In vivo validation of a catheter-based near-infrared spectroscopy system for detection of lipid core coronary plaques: initial results of th...

Positive Vascular Remodeling in Culprit Coronary Lesion is Associated With Plaque Composition: An Intravascular Ultrasound-Virtual Histology Study

BACKGROUND AND OBJECTIVES The relationship between the positive remodeling (PR) of a coronary artery and plaque composition has been studied only in a relatively small number of study population or non-culprit lesion. We evaluated the association between coronary plaque composition and coronary artery remodeling in a relatively large number of culprit lesions. SUBJECTS AND METHODS The study p...